Saturday, August 4, 2012

Glomerular functions check the significance of Nephropathy


Clinical clearance rate often through the determination of various substances to reflect glomerular function. Clear rate measurement, we can find the glomerular filtration rate, renal blood flow, tubular reabsorption and secretion of various substances in order to grasp the kidney function of the degree of impairment. Glomerular function tests include inulin clearance, myogenic hepatic clearance rate, serum creatinine, blood urea nitrogen, glomerular radionuclide clearance, etc..


(1) inulin clearance of inulin as a lower molecular weight polysaccharides composed of fructose-all by glomerular filtration, tubular its absorption, excretion, and therefore inulin clearance (Cin, ) can accurately reflect glomerular filtration rate. Acute glomerulonephritis, chronic renal insufficiency, Cin significantly reduced; chronic glomerulonephritis, renal arteriosclerosis, may have varying degrees of reduction; pyelonephritis, a little lower.


(2) endogenous creatinine clearance rate of endogenous creatinine is primarily through glomerular filtration, tubular almost its absorption and excretion. Therefore, within the creatinine clearance rate (Ccr) measurement, to more accurately reflect the glomerular filtration rate, is a commonly used method of kidney function is good or bad. Acute and chronic glomerulonephritis, Ccr can be reduced; late chronic glomerulonephritis, Ccr decreased significantly; chronic renal insufficiency, and poor prognosis.


(3) serum creatinine concentration of serum creatinine (Scr), depending on the body of nitrogen catabolism and renal excretion; In the case of relatively stable intake of food and in vivo catabolism, blood concentration depends on the ability of renal excretion. Therefore, Scr concentration, to some extent, can understand the degree of impairment of glomerular filtration, can more accurately reflect the kidney function. Renal failure, uremia, Scr increased.


(4) the concentration of blood urea nitrogen blood urea nitrogen (BUN), depends on the decomposition of the body nitrogen metabolism and renal excretion, to some extent, reflect the glomerular filtration rate is good or bad. Determination of serum BUN can be used as indicators of renal function of the extent of damage and therapeutic. Increased seen in acute glomerulonephritis, chronic glomerulonephritis.


(5) clear the rate of glomerular radionuclide glomerular radionuclide clearance with inulin clearance accurately reflect glomerular filtration rate, and has the advantage of no need to collect urine and continuous intravenous infusion of the drug; subject to radioactive substances into the body, so the pregnancy and lactating women should not be applied.

No comments:

Post a Comment