Friday, August 3, 2012

Treatment Principles for lupus nephritis measures



Systemic lupus erythematosus renal involvement, known as systemic lupus erythematosus nephritis, referred to as lupus nephritis. , About 1/4 to 2/3 of patients with systemic lupus erythematosus involving the kidney caused by lupus nephritis. After lesions of the degree of clinical renal involvement, direct impact on the prognosis of systemic lupus erythematosus, prevention and treatment of lupus nephritis is very important measures of treatment principles are as follows.
(1) general treatment to avoid light stimulation, wearing broad-brimmed straw hat in the summer when they go out, to avoid direct irradiation of ultraviolet light and welding arc. Fever, joint pain, and proteinuria, should rest in bed; edema, high blood pressure, low-salt diet; nephrotic syndrome should be a high-protein diet, and renal insufficiency should be a low protein diet.
(2) prednisone adrenal corticosteroids such as prednisone, treatment should be carried out as soon as possible and in sufficient quantities to use. Start can be daily 0.75 ~ lmg / kg administered three times daily, after symptoms changed to the morning fasting Dayton clothing 40mg or so. The condition is generally four to seven weeks of remission, proteinuria was negative. A week for 1 to 2 weeks decreasing 5mg, gradually replaced by the next day serving Dayton. The ideal treatment is changed every other day for 3 to 4 months after Dayton clothing, 20mg, to maintain more than 1 year.
(3) The steroid and immunosuppressive therapy commonly used prednisone plus cyclophosphamide, prednisone plus azathioprine, prednisone plus cyclosporine A treatment. Used in combination, can reduce the lupus nephritis, proteinuria, control of disease activity and reduce mortality.
(4) commonly used heparin anticoagulant therapy, Danshen preparations, low molecular weight dextran, venom antithrombotic enzymes. This treatment enables some patients with nephrotic syndrome, proteinuria decreased blood hypercoagulable state improves.
(5), Kunming Mountain Begonia and Tripterygium preparations for treatment of Tripterygium and Tripterygium Begonia preparation, Chinese traditional medicine "hormone", with the role of regulation of the immune, inflammatory, analgesic and reduce proteinuria, 50% to 70% of lupus nephritis. In combination with the hormone, can significantly improve efficacy.
(6) of critically ill and terminally ill treatment of severe lupus nephritis with rapidly progressive nephritis, can be used steroid pulse therapy and plasma exchange therapy. General immune complexes in the blood to prevent nephritis development and improving renal function. Advanced lupus nephritis into renal failure, should be based on the indications for dialysis replacement therapy; medications to control lupus activity may be considered to be in stable condition after the transplant.


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