Tuesday, July 31, 2012

Lupus nephritis early symptoms


A medical history and symptoms
More common in young women, the light asymptomatic proteinuria (<2.5g / d) or hematuria, edema, hypertension; in most cases, proteinuria, red white blood cells in urine, urinary tube, or was nephrotic syndrome accompanied by a small number of cases the onset of edema, hypertension, or renal dysfunction, nocturia is more common; rapidly, renal function rapidly deteriorating. The majority of renal involvement occurs in fever, arthritis, skin rashes and other extra-renal manifestations, severe cases lesions often rapidly involving the serosa, heart, lung, liver, blood-forming organs and other organs and tissues, and with the corresponding clinical manifestations. About 1/4 of patients with kidney damage as the initial presentation. For women of childbearing age have kidney disease should be a routine examination of the disease-related serological indicators. The diagnosis of this disease is mostly with reference to systemic lupus erythematosus developed in 1982 by the American College of Rheumatology diagnostic criteria.
Second, the examination revealed
The acute phase of fever is more common; majority of patients have anemia appearance; facial butterfly erythema characteristic changes. Accompanied by joint swelling, hair loss, rash, heart murmur or pericardial effusion, hepatosplenomegaly, lymphadenopathy and varying degrees of edema or pleural and peritoneal effusions, etc.

What cause lupus nephritis

This disease is the body's endogenous (self) antigen by the immune complex diseases and disorders associated with T cell function. To be investigated in the patients serum antibodies have a variety of anti-autologous tissue composition, including anti-DNA antibodies, especially anti-double stranded DNA (natural DNA) antibody is more effective than positive, patients with circulating immune complexes separable into natural and single-stranded DNA antibodies and antigens; eluted from glomerular immunoglobulin antibody can be combined with natural and single-stranded DNA antigen.
A humoral immune changes in which DNA and anti-DNA antibodies form immune complexes play a major role. (1) virus triggering factors: more studies confirm the disease is an RNA virus - type C virus. C-type virus on the one hand may damage the cells, so that the release of DNA was highly immunogenic; the other hand, may be due to this virus reverse transcriptase, the virus's own RNA copied into DNA, leaving the body to produce anti-DNA antibodies, both anti-viral replication generated by DNA, but also against human DNA. (2) Bacterial toxins and lipopolysaccharide trigger factors: Some bacterial lipopolysaccharide composition injected into mice and observed that can contribute to the DNA of mouse tissue release to the blood circulation and the role of mitogen to promote the activation of B lymphocytes to produce antibodies, so that these substances promote the role of DNA antigen-antibody complex to generate. (3) autologous tissue damage to the release of DNA: the patients in vivo lymphocyte cytotoxic antibodies. Medium molecular weight soluble DNA immune complexes through the blood circulation to the kidneys (or other organs) and deposited in the glomerulus.
Cellular immunity: the suppressor T cell function and decline in the number. The reason is that the existence of cytotoxic antibody (anti-lymphocyte or thymocyte antibody) in serum, thereby undermining the T cells. Decreased suppressor T cells, on the one hand, to reduce the inhibition of antibody formation, on the other hand may be due to the release of lymphokines decreased to inactivate the ability of helper T cells, helper T cells to promote antibody production capacity increase, the total The humoral immune (antibody formation) strong.
(3) genetic factors, patients who have family history of the same disease accounted for 0.4% to 3.4.

How to treat lupus nephritis type 4


Lupus nephritis type should be treated? Common clinical treatment with hormones or immune agents to directly control protein, but patients are very likely to relapse, especially hormone reduction or is discontinued, and patients are very easy to re-infection, this is because of this treatment, symptomatic treatment does not, ignore the root cause of ----- the treatment of kidney epithelial cells to repair, so the 4 treatment of lupus nephritis is also based on the root cause of symptoms after diagnosis of the disease, the treatment with the job!
Conventional treatment of lupus nephritis 4
4 treatment of lupus nephritis, treatment decisions should be based on clinical manifestations, laboratory tests and pathological changes in the program. Is generally believed that clinical symptoms are mild, normal glomerular structure or mild lesions, mild mesangial proliferative available antimalarial treatment of lupus nephritis type 4, which can increase with low-dose hormone oral.
Lupus nephritis, the use of steroid and cytotoxic therapy, but should pay attention to the proteinuria after this type of treatment is difficult to completely overcast, and the progression of the disease mostly benign after, in the course of treatment, to prevent the treatment of excessive risk of drug the risk of side effects. Type 4 lupus nephritis in the clinical symptoms of nephrotic syndrome or rapidly progressive glomerulonephritis, or even progressive renal failure have favored steroid and cytotoxic drugs in combination therapy.
The proper treatment of lupus nephritis 4:
Lupus is a connective tissue disease, pathological damage can affect various body systems, especially the more common kidney damage, lupus kidney damage caused by the nature of the injury of renal intrinsic cells, kidney fibrosis, sclerosis, and ultimately lead to impaired kidney function. If only symptomatic treatment, and kidney damage is not repaired, then, even if the symptoms temporarily alleviate the condition is also very vulnerable to repeated, it is recommended Integrative Medicine, Western medicine to control symptoms, Chinese medicine to repair kidney damage.

How to treat lupus nephritis



"How lupus nephritis treatment?" Lupus nephritis, etc. Most of the patients concern, Shijiazhuang kidney disease hospital for a brief "how therapy of lupus nephritis?




Lupus nephritis treated? The treatment of lupus nephritis is a traditional Chinese medicine and Western medicine the two treatment approaches. So the two which is more effective? That issues of concern to everyone, this site make the following introduction for you I hope for your help!




That medical treatment of lupus nephritis:


1) glucocorticoids: prednisone-based drugs, conventional dosage of 0.8 1mg.kg_1. D_1, eight weeks after treatment began the gradual reduction, the reduction rate must be controlled, maintenance treatment to 10_20mg / d for at least two years . Necessary to give methylprednisolone, 0.75g.m2_1. D_1 intravenous infusion for three consecutive days as a course. Methylprednisolone followed by prednisone maintenance therapy, efficacy, side effects. Need to be adjusted when the following conditions occurs glucocorticoid medication: difficult to control diabetes or high blood pressure, severe osteoporosis, steroid psychosis, severe infection and severe myopathy.


2) cytotoxic drugs: even without cytotoxic drugs, glucocorticoid treatment of proliferative glomerulonephritis, the treatment more fully in combination with cytotoxic drugs, but cytotoxic drugs often take 3-4 months before onset. Cytotoxic drugs in the treatment of the beginning of the application, can also be added with the hormone is not satisfied with the results. Studies have shown that, added to enhance the efficacy of cytotoxic drugs can reduce the hormone dosage. To cyclophosphamide (CTX) pulse therapy, 750mg/M2 in normal saline slow intravenous infusion in more than one hour, 1 time / month, once every six months.


The absence of disease activity every three months the impact of a stable after treatment for 1-2 years may be considered withdrawal. Side effects: In addition to the common side effects, but also the occurrence of menstrual disorders (16% -20%), reproductive failure (19%), hemorrhagic cystitis (17%), bladder (2%). Used in conjunction with small doses of glucocorticoids can enhance efficacy and reduce toxicity. CTX medication need to be adjusted in the following circumstances: refractory hemorrhagic cystitis, severe nausea, vomiting, radiotherapy, previous history of cancer, bone marrow suppression caused by reduced blood cell damage resulting from blood (peripheral blood cells decreased excluded).


Visible: At present, the Western medicine treatment of lupus nephritis is not fundamentally in the treatment, and easily repeated; drug control is not good, easy to produce many complications, give the patient a lot of pain, quality of life has become is very low. So, lupus nephrotic how to treat good?


Of Chinese and Western approaches to treatment of lupus nephritis - of the micro-penetration therapy of Chinese medicine


Its therapeutic mechanisms are: vasodilators, anti-inflammatory, anticoagulant, anti-blood viscosity, degradation fibrosis substances blocking renal fibrosis progress, intrinsic cells to repair damaged and renal function and rebuild the proper structure of the kidney .


The micronized Chinese medicine penetration treatment of lupus nephritis, by Huoxuetongluo, blood stasis and disinfection, repair the new health and the three stages of treatment, each stage of the patient will have a different turn for the better performance. The kind of innovative therapies that eliminate the side effects of oral drug, but also up to the purpose of the drug ingredients enter the effective lesions. Moreover, the kind of innovative therapies and clinical practice has proved both effective and convenient.


Lupus nephritis treated? Did you know? Specific treatment of lupus nephritis, you can contact with our online kidney specialists, experts will be one-on-one answers to your questions!

Daily health measures for lupus nephritis


Lupus nephritis daily health measures "are the majority of patients concern, Shijiazhuang kidney disease hospital brief measures of day-to-day care of lupus nephritis
Patients with lupus nephritis do daily health measures for the treatment of lupus nephritis.Following the health of lupus nephritis. First, the emphasis on physical factors, systemic lupus erythematosus a close relative incidence as high as 5% to 12% monozygotic twin incidence of up to 69%, the relatives of lupus patients with other autoimmune diseases such as rheumatoid, dermatomyositis, scleroderma, xerosis and psoriasis incidence, while the female is multiple in patients with low testosterone levels, then the endocrine factors, especially the incidence of estrogen in the body's levels of lupus patients with lupus nephritis related. Therefore, based autoimmune disease lupus erythematosus, including relatives of autoimmune disease, should be on high alert, once the disease should be thought of autoimmune disease, once the risk of autoimmune disease, should be actively treated. prevent the occurrence of lupus nephritis resulting in renal impairment. Second, aggressive treatment of viral infection viral infection may be related to the occurrence of systemic lupus erythematosus. Therefore, we should actively treat various viral infections. In particular, this "disease" for the upper respiratory tract infection, must not be taken lightly. "The wind is riddled with long, many seriously ill with colds start incidence jeopardizing the crowd. Third, pay attention to drug toxicity and lupus erythematosus-related drugs hydralazine, procainamide, isoniazid, methyldopa, chlorine & P hydrochlorothiazide and quinidine, etc., especially the previous two common. Hydrazine, amine, thiol groups may be related to the drugs. Lupus genetic basis of lupus erythematosus patients, it should be noted that the toxicity of these drugs may be produced by lupus patients. Fourth, avoid sunlight exposure to ultraviolet radiation increase the disease of lupus nephritis is more common. UV allows DNA is converted to thymine dimer, leaving the antigen-enhanced to promote the occurrence of systemic lupus erythematosus. Therefore, patients with lupus nephritis in their daily lives should avoid prolonged exposure to strong sunlight in order to reduce the renal damage caused by excessive ultraviolet radiation [learn more about information, click on the consultants] Tips: patients do day-to-day care combined with regular treatment would be the treatment of lupus nephritis and cure a significant role.

The treatment of lupus nephritis


The treatment of lupus nephritis [Tags: Key words] are the majority of patients concern, Shijiazhuang kidney hospital for brief treatment of lupus nephritis




Patient Question: I suffer from wolf nephritis, cyclophosphamide pulse therapy before, but the effect was not significant, hello there is no other treatment options?


Patients reply:


Go directly to the pressure protein is a common clinical treatment under normal circumstances with hormones or immunosuppressive agents, but ignores the root cause of kidney damage - kidney mesangial cells and basement membrane damage, just keep lowering protein, occult blood , where pain governance where ignored the fundamental damage toward the treatment of misunderstanding, leading to the aggravation of the disease. Recurrence of kidney function, can also cause other organ damage, taking most of the drug a day to see results, but also increased the burden on the kidneys, causing the majority of household debt, affecting normal life, lost confidence in life, it seems completely disappeared completely became a luxury!


Had nephritis, nephritis itself is not terrible, horrible, no systematic treatment to delay disease missed the best time for treatment, so if it is found necessary to the system of treatment can not be purely symptomatic treatment. pathological damage from the start, our hospital for treatment is the treatment of Integrative Medicine, which means that symptomatic treatment to repair the damaged kidney, as long as the repair in place of protein or occult blood will disappear naturally, measures of treatment is comprehensive use of vasodilators, anti-inflammatory, anticoagulant, and measures of degradation of harmful substances. And the hospital of Chinese medicine is topical, avoid the past, traditional Chinese medicine absorbed through the gastrointestinal tract damage the gastrointestinal mucosa is gastrointestinal function decline and reach the drawbacks of low drug concentrations of the affected area, the implementation of target directed drug directly to the affected area, the treatment completely, and repeated low, to radically improve the internal environment of the kidney.

Prognosis and treatment of lupus nephritis


Prognosis and treatment of lupus nephritis "are the majority of patients concern, Shijiazhuang kidney disease hospital a brief introduction to the prognosis and treatment of lupus nephritis
Prognosis and treatment of lupus nephritis lupus nephritis type is divided into six types, is different for each type of disease treatment, the prognosis is different. In the traditional areas of the treatment of lupus nephritis is the use of hormonal drugs, the dosage is to change the degree of clinical manifestations and disease and lupus nephritis.
The prognosis and treatment of lupus nephritis type Ⅰ:
The renal tissue of lupus nephritis type Ⅰ, light microscope, normal structure, immunoglobulin and complement deposition in the use of immunofluorescence. The prognosis of this type of lupus nephritis does not require special treatment, but still need follow-up study to prepare for any eventuality.
The prognosis and treatment of type II lupus nephropathy:
Lupus nephritis type Ⅱ, this type of renal injury in glomerular mesangial area, which no mesangial cell proliferation is known as type Ⅱ A, these are mild mesangial lesions prognosis without treatment; Ⅱ B lesions mesangial area seen in mesangial cells and mononuclear cell proliferation, to urinary protein 1g/24h and low complement C3 hyperlipidemia accompanied in the treatment of the need for six weeks between -3 treatment, usually with prednisone 20mg / d, continued with the improvement in reduction of the disease remain. Type Ⅱ lupus nephritis interstitial and vascular damage.
Prognosis and treatment of type Ⅲ and type Ⅳ lupus nephritis:
Type Ⅲ glomerular damage in lupus nephritis has been more significant, In addition to the mesangial focal stage glomerular capillary has been involved, but no more than 50% of the total glomerular Lupus nephritis type Ⅳ and Ⅲ type of the type of injury, only the damage is more extensive than 50% glomerular damage, and even more serious degree.
Pathological damage similar between the two treatment programs similar prognosis.Development of the two types of lupus nephritis in 10 years to end stage renal disease more than 50 percent, so we must strengthen the treatment to prolong the survival period of the two types of patients, is quite important. Under normal circumstances in the prognosis of treatment with glucocorticoids and cytotoxic drugs. The glucocorticoid prednisone-based, conventional dosage advice of a doctor, and the need to maintain a specific time we must obey the doctor's orders. If necessary time to give methylprednisolone maintenance treatment, that the efficacy and side effects. Cell poison drug is also commonly used treatment, glucocorticoid with the cell poison, drug combination more fully. But the cytotoxic onset interval is longer, often 3-4 months before onset.
The prognosis and treatment of lupus nephritis type Ⅴ:
Ⅴ type of lupus nephritis is divided into four types, type Ⅴ, a comparison with patients with idiopathic membranous nephropathy; type Ⅴ b diffuse mesangial changes; Ⅴ type c there are segmental proliferation or segmental sclerosis ; Ⅴ d-exist with diffuse proliferative glomerulonephritis, similar regardless of clinical manifestations of this type, or histological type Ⅴ lupus nephritis.
The type of lupus nephritis treatment to distinguish between what are membranous lupus nephritis or diffuse lupus kidney disease, drugs and treatment approaches used by different pathological distinct, but also to the type of symptomatic treatment.
Ⅵ lupus kidney disease prognosis and treatment:
Ⅵ type of lupus nephritis are the end of lupus nephritis, lupus nephritis type accounts for only 2%.
Prognosis and treatment of lupus nephritis do not quite understand, you can continue to read the following related content.

Lupus nephritis patients need to pay attention to diet


"Patients with lupus nephritis how attention to diet?" And other issues of concern are the majority of patients, Shijiazhuang kidney disease hospital for a brief introduction to "lupus nephritis patients how to pay attention to diet?"
Lupus nephritis patients how to pay attention to diet?
Most patients with lupus nephritis is very concerned about their diet. Indeed, the diet is good or bad treatment of the disease to some extent. So, in patients with lupus nephritis how to pay attention to diet?
Due to the loss of lupus nephritis induced by large amounts of protein, each patient daily average loss of 2 g of right and left, so will cause the Protein content in the blood drop, the daily added some high quality protein to maintain the balance of the body's protein. The so-called quality protein is mainly referring to animal protein, such as fish, meat, chicken, duck, etc. can be decided according to their own economic situation and the usual appropriate to eat, to supplement the amount of protein lost in the kidneys, but can not eat too much, so as to avoid indigestion. You can also eat some fresh vegetables to supplement the body's vitamin, do not "diet".
Most people listening to rumors that suffering from a disease that can not eat can not eat, desperately dieting, resulting in the weakening of the body is not conducive to the body's resistance to disease. Due to renal ischemia, the kidney renin secretion, activation of angiotensin and high blood pressure, due to row sodium functional decline, so that water and sodium retention, and more emphasis on high blood pressure, so to limit daily sodium intake the amount of general daily 3 grams right and left, while to add to the activation of vitamin D to help calcium absorption. Going to wear more clothes, pay attention to the prevention of colds, so as to prevent exacerbations.

What is a urinary tract infection



"What is the concern of urinary tract infections, nephritis, lupus nephritis are the majority of patients, Shijiazhuang kidney disease hospital for a brief introduction to" What is a urinary tract infection
Urinary tract infection (urinary tract infection, UTI, or urinary tract infection referred to as urine sensation) in a broad sense refers to how the amount of the propagation of microorganisms in the urinary tract caused by urinary tract inflammation can be with or without clinical symptoms. According to the different pathogenic microorganisms and urine flu can be divided into bacterial and fungal urinary flu. But for the most common bacterial urine sensation. Clinical urine sense of that term refers to a bacterial infection of the urinary tract. This urinary tract infection focuses on cystitis, acute and chronic pyelonephritis and asymptomatic bacteriuria. Where the authenticity of bacteria in urine are urine sensation. The presence or absence of clinical symptoms, the urine sensation can be divided into the urine flu symptoms and Asymptomatic Bacteriuria Asymptomatic Bacteriuria refers to patients with true bacterial urine without urinary clinical symptoms of the flu, is a sense of asymptomatic urine; both authenticity of bacteria in urine and clinical symptoms as symptoms of urinary sense. UTI is divided into upper urinary tract infection according to the site of infection and lower urinary tract infection, the former pyelonephritis, the latter mainly for cystitis; with or without urinary tract function or anatomical abnormalities, can be divided into UTI complexity and complexity of the two, the former is associated with urinary tract obstruction, stones, urinary tract congenital malformations or vesicoureteral reflux with anatomic or functional abnormalities of the UTI, or chronic renal parenchymal disease on the basis of the UTI, the latter no the above situation. Urine flu is a very common disease, its onset rate according to census statistics in China accounted for 0.91% of the population. Men and women can be onset, particularly common to women. About 30 percent of the women in their life who have had the sense in urine, while about 6 percent a year for women suffering from symptomatic urinary sense. The reason is that the female urethra is short and straight, the urethral opening and anus adjacent, more women of reproductive age urethra trauma and contamination. Urinary tract infection Chinese medicine stranguria "," back pain "in areas such as. "Low back pain back pain symptoms. "Card shower" for frequent urination short astringent, dribbling tingling, want not entirely, Juji lower abdomen, or pain cited waist for the main symptoms can be divided into: hot shower, discredited, Shilin, gas shower cream shower LO shower.

How to reduce kidney damage for Lupus nephritis patients


Lupus nephritis how to reduce kidney damage and other issues of concern are the majority of patients, Shijiazhuang kidney hospital for a brief "lupus nephritis how to reduce the renal injury
In the treatment of lupus nephritis, the use of immunosuppressive agents to control disease activity is certainly important, but only concerned about the treatment of lupus and ignore the protection of the kidneys may eventually lead to treatment failure, kidney failure. In fact, due to more serious kidney damage caused by lupus activity, even if the lupus is inactive, kidney disease can still continue to increase, kidney sclerosis, leading to renal failure. Thus, in the course of treatment of lupus nephritis, renal protection must be a message, to avoid kidney failure. If some patients relapse due to lupus activity or delayed treatment, treatment may have varying degrees of renal failure, should try to make the development of kidney damage. So these factors can aggravate kidney damage?
First, high blood pressure. Lupus nephritis is often complicated by high blood pressure, hypertension is the strongest risk factors for worsening renal function in lupus nephritis patients to a message with or without increased blood pressure, high blood pressure to ensure the strict control.
Followed by urinary protein. Urinary protein not only reflect glomerular damage, but also cause tubulointerstitial damage, leading to one of the risk factors for kidney disease progress. Reduce proteinuria can reduce the damage to the kidneys play a role in protecting the kidneys. Angiotensin-converting enzyme inhibitors such as benazepril and angiotensin receptor antagonists, such as Diovan and other drugs can reduce urinary protein, slowing renal sclerosis, play a role in protection of the kidney. Such as urinary protein persists, even with normal blood pressure can also use these drugs.
Third: nephrotoxic drugs. Some drugs often have damage to the kidneys, such as sulfa, card neomycin, gentamicin, polymyxin B and other antibiotics; Chinese medicine (especially manshuriensis,, anti, etc.); analgesic agents. Avoid use of unnecessary drugs, so as not to add to your kidney damage. Fourth: the infection. In the process of treatment of lupus nephritis (especially in the first few months of treatment) prone to infection. Infection often leads to repeated illness or aggravated in their daily lives should be to prevent, avoid going to crowded places, reduce the incidence of infection. Once the infection should be timely treatment, timely medication.
Fifth: obesity. Obesity is a major problem of public health hazards in the current global context. Obesity, hyperlipidemia, hypertension, coronary heart disease risk factors, can also be an increase in urinary protein, increased kidney damage. 

Sunday, July 29, 2012

Clinical manifestations of lupus nephritis in children


Clinical manifestations of lupus nephritis in children Child lupus nephritis are the majority of patients concern, Shijiazhuang kidney disease hospital a brief introduction to the clinical manifestations of lupus nephritis in children
Clinical manifestations of lupus nephritis in children
Children with systemic lupus erythematosus (SLE) is a typical self-reactive disorder characterized by autoantibodies in children with blood in large amounts of anti-nuclear antigen, and the performance of multi-system damage. The highest of disease onset, rate of girls in Asia. The main clinical manifestations are the following:
A. Onset age and sex: more common in women, accounting for about 80 to 90 percent in pediatric cases aged 10-14 years, the most common, accounting for 1/3 5 to 10 years of age of onset, infants and young children is rare.
Two. Performance of kidney damage: the early course of 25 to 50% of urine or renal dysfunction, future development to 80 percent of the children apparently kidney damage performance, more common than in adults.
(1) Clinical manifestations: no characteristics, hematuria, proteinuria, hypertension is more common: urinary protein is almost there, with varying degrees of edema, 50% right and left with nephrotic syndrome; persistent microscopic hematuria is common but there is no separate the existence of coverage; 40 percent have high blood pressure. About 50% decline in renal function and even can be manifested as acute renal failure. Often tubular dysfunction. Clinical classification: asymptomatic hematuria or urinary protein, acute nephritis, nephrotic syndrome, rapidly progressive glomerulonephritis, acute renal failure, chronic nephritis, acute renal tubular acidosis.
(2) the time: as the first symptom; or systemic symptoms appear several years after, according to the statistics 60% of LN onset of March, 88 percent in three years, while 27% of renal involvement occurs in the pathogenesis of After five years or more.
3. Extrarenal manifestations
(1) rash: facial butterfly rash common sun intensified.
(2) joint symptoms: joint and muscle pain may involve the limbs, the size of joint, showing acute inflammatory process.
(3) cardiovascular anomalies: The lesions may involve the endocardium, myocardium and pericardium, a few may have vasculitis, and Raynaud's phenomenon.
(4) Respiratory: interstitial pneumonia, pleurisy, pleural effusion.
(5) of the nervous system: mild involvement common, such as judgment, short-term memory loss, abnormal behavior, headache. In addition, acceptable performance of the relatively rare mental illness, chorea, convulsions.
(6) Gastrointestinal: mild gastrointestinal tract involvement common, such as nausea, anorexia, abdominal pain, liver or spleen of 30 to 40 percent.
(7) of the blood system with the most common: anemia, followed by white blood cells, thrombocytopenia.
(8) Other: fever, malaise, weight loss, photosensitivity, hair loss and swollen lymph nodes, etc.
These are the clinical manifestations of lupus nephritis in children, hoping to help the parents and friends! If your child has these symptoms, please go to regular hospitals, so as not to delay the child's treatment.

Food taboos of lupus kidney disease patients


Diet contraindication for patients with lupus nephritis? "Issues of concern are the majority of patients, Shijiazhuang kidney hospital for a brief introduction of any dietary restrictions for patients with lupus nephritis?
Food taboos of lupus kidney disease patients? The experts found: Recurrent high rate of lupus nephritis. Approximately 20% of patients with lupus nephritis will be 10 years development of uremia, one of the leading cause of death of patients with systemic lupus erythematosus. That has also become a great concern for of Xu lupus nephritis patients and family members!
Why lupus nephritis repeated high? Why, in a very short time developed into uremia it? The main reason is that the diet of patients with lupus nephritis was not standardized.For patients with lupus nephritis, follow the dietary guidelines of lupus nephritis is critical, as will make lupus nephritis to control treatment.
Lupus kidney disease patients of any dietary restrictions following:
1, patients with lupus nephritis should not eat diet
Patients with lupus nephritis should not eat less food with enhanced light-sensitive role of food: such as figs, milk vetch, rape, the yellow Bullacta and celery should be avoided, such as eating sunlight. Mushroom, mushrooms, mushrooms, and certain food dyes and tobacco also have a potential role for induced systemic lupus erythematosus, but also try not to eat or less edible.
2 lupus nephritis patients with high-protein diet
Systemic lupus erythematosus patients with kidney damage often large amounts of protein are lost from the urine, can cause hypoproteinemia, and therefore must add enough quality protein, can drink milk, eat soy products, eggs, lean meat, fish protein-rich foods.
Lupus nephritis patients should be low-fat diet
Less active systemic lupus erythematosus patients, poor digestive function, should eat light and easily digestible food unfit for human consumption containing more fat and greasy food.
4 patients with lupus nephritis should be low-carb diets
Could easily cause a systemic lupus erythematosus patients taking long-term glucocorticoid steroid diabetes and Cushing's syndrome, it should be appropriate to control appetite, eat less sugar content of foods that are high.
5, lupus nephritis patients should be low-salt diet
Corticosteroids or patients with kidney damage easily lead to water, sodium retention, causing swelling, so the low-salt diet.
Lupus nephritis patients should supplement calcium
Prevent osteoporosis caused by glucocorticoids; eat more vitamin-rich vegetables and fruits.
In short, lupus nephritis is not an incurable disease, so patients unnecessary fear. In addition to the normal medication by your doctor, in life, pay attention to the daily care and diet to restore. As the control treatment of lupus nephritis from repeated. In addition, patients with lupus nephritis consolidation therapy at home, such as the regulation of the diet problems, or other problems lead to lupus nephritis repeated. Patient friend to be sure to go to a regular hospital, in order to avoid adversely affected by illness, which developed into uremia.

Lupus patients can do physical exercise?

Lupus patients should keep moving, to avoid excessive bed rest. Activities can enhance muscle strength, enhance body endurance of the disease is very beneficial. But also a message to protect their existing inflammation damages the joint, it is recommended for swimming, walking, cycling and other activities. Some recreational activities, especially some of the ligaments, tendons and other demanding projects, such as rowing, weightlifting, golf, tennis, and other needs vary.

Lupus nephritis improved case


Patient: Miss Liu, female, 26 years old, unmarried, Sichuan
    Chief Complaint: backache, leg swelling, nausea, vomiting June
    History: the patient face found erythema, hand, foot and cold, mainly as fatigue, weakness, dizziness, lower back and joint pain, irregular menstruation, the local hospital diagnosed the wolf
Wound nephritis. Prednisone given Western medicine, Chinese medicine capsules, etc., a total of 29 days of hospitalization, his condition improved, but more than a month of relapse and increase the patient for further treatment, to my
Our hospital for treatment.
    Admission examination: T 36.5 ℃, R 18 times / min P 84 times / min, Bp140/70mmHg normal development, nutrition in general, Shen Qing, the spirit of the poor.
    The admission of the laboratory tests: proteinuria (), urinary occult blood (), initially diagnosed as: lupus nephritis.
    Micro-based medicine penetrate therapy symptomatic treatment: start with the fundamental pathogenic lupus nephritis, the use of micro-based traditional Chinese medicine penetration therapy, immune disorders caused by immune complex deposition in that morbid reflected containment
System, termination of further injury and apoptosis of renal intrinsic cells, micro-based medicine infiltration therapy of active substances can also promote the synthesis and degradation of extracellular matrix homeostasis, blocking extracellular
Matrix abnormal proliferation proliferation and deposition.
    Infiltration therapy of micro-based traditional Chinese medicine to penetrate symptomatic treatment given after the patient's admission, and with the psychological, the delight of clear guidance, a total of 35 days after hospital admission, the patient's illness has been apparently improved prospective doctors
Discharged home to continue the consolidation therapy.
    Check discharge: patients with no nausea, vomiting, edema disappeared, lumbar pain embolism disappeared, no palpitation, chest tightness, physical examination: T 36.5 ℃, R 18 times / min, P 84 beats / min,
Bp 120/80mmHg, God clear language interest, the spirit of better. Proteinuria was negative, urine occult blood was negative.
    The doctor's advice: lupus nephritis is often accompanied by multiple organ dysfunction, treatment, recovery process more difficult, so to remind patients and their families must adhere to consolidation therapy. And the life and
The diet should be strict adherence arrangements. First message on infection control, exposure to sun and chemicals induced lupus activity. Again is a food taboo.

Chinese medicine treatment of lupus kidney


Proprietary Chinese medicines for the treatment of lupus kidney? I have lupus nephritis three months, now discharged from hospital at home treatment, which experts tell me some of the proprietary Chinese medicines to treat lupus kidney, I want to hurry up better, Thank you experts!
Lupus nephritis is a secondary disease to prevent in the treatment of patients with lesions or patients with impaired renal function, the use of proprietary Chinese medicines to treat lupus nephritis, can achieve good results. The general treatment of lupus nephritis proprietary Chinese medicines used in clinical practice have the following:
A. Slow Kidney: Each 15ml, 3 times a day. For yin and yang deficiency.
Two. Nephritis flavor tablets: 8 each, 3 times a day.
3. Liu Wei Di Huang Wan: 1 pill each time, twice daily. For liver-kidney.
4. Tripterygium: Each 20mg, 3 times a day. For toxic heat flaming type.
5 In Tripterygium hypoglaucum slices: each 100 to 200mg three times daily for excessive noxious heat type.
Lupus nephritis is not taking some oral medication can be cured, I think you just attached help to want to take some of the treatment of lupus kidney proprietary Chinese medicine, so I suggest you syndrome treatment. The onset process, infection, immune dysfunction, a large number of pathogenic immune complexes appear, pathogenic immune complex deposition in lupus nephritis such a process. In the treatment of knowledge of use of single drugs of Western medicine hormones and other ingredients, obviously can not do to cure the patient because of hormones and other immunosuppressive drugs can only temporarily suppress the immune function, thereby reducing the generation of pathogenic immune complexes and deposition, and temporary relief from the renal inflammatory response, so such a complex pathogenesis of lupus nephritis is clearly not enough. The use of proprietary Chinese medicines for the treatment of lupus nephritis. This will avoid the Western recurrent episodes refractory, toxic side effects and other issues.
Infiltration therapy of micro-based medicine is now generally used. Made of proprietary Chinese medicines for the treatment of lupus nephritis after the processing of high-tech, pharmaceutical ingredients for traditional Chinese medicine to overflow more fully, the drug is more powerful, more easily absorbed by the body. Infiltrate the administration and then driven by electronic drug penetration instrument in the kidney area of ​​the patient's waist, so that you can make medicinal components directly to patients, pharmacodynamics can be a powerful play.
The use of proprietary Chinese medicine treatment of lupus nephritis can be achieved by the potency quickly to play the role of the human body as soon as possible absorption. Is a good choice for the treatment of lupus nephritis. Would like to take proprietary Chinese medicines to treat lupus kidney, but also the best or find Chinese medicine experts dialectical analysis guidance before taking. If you have any questions do not understand, with online kidney specialists of the hospital in a timely manner.

Reasonable treatment for Lupus nephritis ?


Lupus nephritis treatment reasonable?
Lupus nephritis in the clinical treatment is more complicated. If you are patients with lupus nephritis, in the course of treatment, please be sure to note the following:
(1) lupus nephritis should be long-term treatment, some patients even require lifelong treatment. The disease has a strong genetic background, so far, although oral medication can be a good remission of disease, but there are certain side effects, micro-based medicine to penetrate therapy drugs for external use, in the same time to improve efficacy, greatly reducing the drug side effects. Patients in the process of application of the drug do not listen to Youyi unauthorized withdrawal, so that will be detrimental to the treatment of the disease, making it prone to repeated.
(2) installments according to the degree of disease activity in treatment. Lupus in the activities of very serious kidney inflammation usually require large doses of several drugs in combination therapy (such as hormones, Xiao interest, called the induction period of treatment), is designed to quickly control the inflammation, to prevent kidney damage continues to increase. When converted to small doses of drugs in the control of the activity maintenance therapy to prevent recurrence and to protect kidney function (maintenance therapy). Long-term use of large doses of medication will inevitably bring about complications, but without maintenance therapy, repeated activities can be caused by lupus, kidney damage has been increasing, and finally may be developed for renal failure. Therefore, during treatment, according to the lupus activity, timely adjustment of the treatment. Have a long-term planning, should his condition improved random drug withdrawal, or blind to long-term medication.
(3) treatment options vary. Individual severity of patients with lupus nephritis different, there are many types of different patients, different types of different treatment options should be taken. Clinical widespread use of large doses of the hormone in combination with cyclophosphamide intravenous treatment is not suitable for all patients with lupus nephritis. Should be based on clinical disease and renal biopsy under the guidance of a doctor choose to use anti-lupus drug. Long-term maintenance therapy, the combination of Chinese and Western therapy is not only effective, less side effects, patients can also live and work.
(4) pay attention to prevent complications. This point is often overlooked. Lupus nephritis patients in the treatment process is prone to various complications such as infections, cardiovascular complications, femoral head necrosis, severe cases can be life threatening. Key to reducing complications, the key lies in the rational use of anti-lupus drug, regular follow-up to early detection and treatment. The use of large doses of medication, should be relatively isolated, not in public places, and attention to climate change. Fever and other symptoms of infection and timely treatment.
(5) to prevent the recurrence of lupus. Any infection, sunlight, chemicals, contact or pregnancy can induce lupus activity. Female patients should avoid pregnancy, the disease is uncontrolled. Such as pregnancy must also must be under the guidance of a doctor.
(6) stressed the idea of ​​the overall treatment. Because lupus is a systemic disease, so in control lupus nephritis at the same time, you should pay attention to protection of renal function and other vital organs such as heart, lung or brain treatment and protection.
In summary, patients with lupus nephritis must not listen to Youyi and credulous recipe, accept unprofessional, unscientific, non-standard method of treatment. Should choose a formal specialist hospitals, according to the characteristics of their own condition by a doctor to develop a long-term treatment and recovery plan, and regularly checked. So as to effectively control the disease, the greatest extent possible to block the progression of the disease and reduce drug complications and to achieve the best therapeutic effect, in order to maintain a better quality of life and ability to work.

Drugs for Lupus nephritis


Lupus nephritis which therapy is better? Lupus nephritis is a secondary kidney disease, not a separate disease, timely understanding of the patient history to understand the pathogenesis of the patients before they can develop the right treatment. The cause of lupus nephritis main reason is the main reason to cause the wolf Cang nephritis is due to chronic viral infections, genetic, hormonal and environmental factors interact to cause immune deficiency, immune complex deposition resulting in epithelial cells of the synthetic-rich Yin charge barrier function is compromised.
The confirmed wolf Cang nephritis, most hospitals now commonly used in clinical intravenous injection of large doses of hormones in combination with cyclophosphamide treatment, these two drugs can cause a decline of immunity, in addition, the excessive use of antibiotics, but also can easily lead to superinfection of lupus nephritis.
Only timely treatment of the symptoms of lupus nephritis in order to avoid harm, the patient should be selected according to their own situation to heal individuals of varying severity of disease in patients with a variety of types, different types should be taken to a different treatment for different patients, The program is not suitable for all patients.
Wolf Cang nephritis varied, even the original stable condition, under the influence of certain factors, but also activity in the treatment of wolf Cang nephritis patients have to go to the best regular kidney specialist hospital to receive formal treatment, to keep abreast of changes in renal function, it is recommended that the majority of patients with early treatment.
Of micro-penetration therapy of Chinese medicine to fix the intrinsic cells of the kidney damage, kidney disease rule, "this" to avoid the repeated recurrence of the disease. Micro-based traditional Chinese medicine active substances to activate the function of renal intrinsic cells to reverse and restore normal cell metabolism; to improve the microcirculation impaired kidney kidney aerobic repair the environment, accelerate the natural cellular repair of the damage the kidneys; to improve the damaged kidney within environment, reduce the symptoms of poisoning, and create a relaxed environment for kidney repair and reconstruction; with biphasic immunomodulatory function and metabolism, can control the progress of the disease, and lay a good foundation for the repair and reconstruction of the inherent damage kidney cells; for damage renal repair and reconstruction of nutrients to accelerate the repair process of the inherent damage kidney cells, the gradual repair of renal tissue, and reconstruction of renal function.
The above is information about which therapy of lupus nephritis ". Shijiazhuang kidney disease hospital in addition to the original infiltration therapy of micro-based traditional Chinese medicine, but also fully integrated existing treatment of kidney disease, the formation of kidney disease a of with Shijiazhuang nephropathy hospital characteristics of three-dimensional treatment system, It includes the infiltration therapy of micro-based Chinese medicine as the core blocking renal fibrosis and repair of renal function reconstruction of the treatment of renal functional units of technology. At the same time immunosorbent assay for the core of the blood purification technology security; into the surface to restore renal function.

Lupus nephritis can be cured or not


Lupus nephritis can be cured? Lupus nephritis is the renal inherent cell damage caused by lupus cells into the human body, may also be the performance of systemic lupus erythematosus. The traditional approach to the treatment of lupus nephritis is the hormone and immune agents, which to some extent, can temporarily relieve symptoms, can not repair damaged kidney tissue and kidney function, a temporary solution.
Lupus nephritis can be cured? This problem can not be generalized, as long as the patients with the treatment of experts and doctors, can generally be clinical cure, a fraction of patients will be living wills, life with the treatment causing very serious consequences will result in lupus nephritis uremia virtually increase the difficulty of treatment.
To cure for lupus nephritis, the need to combine Chinese and Western medicine, western medicine governance disease, supplement the shortcomings of traditional Chinese medicine effective slow, reducing kidney tissue damage caused by the slow Chinese medicines. After the micro-based medicine to reach lesions, inflammatory factor inactivation, has been the formation of extracellular matrix degradation, repair kidney damage cells and other effects to block the process of renal fibrosis. Chinese medicine active material expansion at all levels of systemic blood vessels, by increasing the effective systemic perfusion, the damaged cells of the blood supply, oxygen, fundamentally alleviate renal ischemia, hypoxia, cells continue to damage to reduce kidney function.
Lupus nephritis in addition to aggressive treatment will affect the cure, the usual personal care is also very important. Patients maintain a good attitude, we must establish the confidence to overcome the disease, positive and optimistic attitude, and the recovery of the disease, I believe that miracles occur in every patient, but also firmly believe that our medical level, there will always overcome lupus nephritis will not be repeated.
3, the principle of the diet of patients with lupus nephritis? 20% of patients with lupus nephritis in 10 years, developed into uremia, because of the high recurrence rate of lupus nephritis, and regular treatment is a very close relationship with patients adhere to a reasonable diet is also inseparable from the , lupus nephritis eat what treatment?

Appropriate food for patients with lupus nephritis


Lupus nephritis in patients with suitable food:
A low-salt foods: corticosteroids, or patients with kidney damage easily lead to water and sodium retention, causing edema, so the low-salt diet.
2, high-quality protein-rich foods: kidney damage in patients with systemic lupus erythematosus often have a lot of protein is lost from the urine, can cause hypoproteinemia is necessary to add enough quality protein, can drink milk, eat more soy. eggs, lean meat, fish and other protein-rich food.
3, low-fat food: less patients with systemic lupus erythematosus activity, poor digestive function, should eat light and easily digestible food unfit for human consumption containing more fat and greasy food. Vitamin-rich vegetables and fruits, to prevent osteoporosis caused by glucocorticoids, eat more vitamin-rich vegetables and fruits.
In addition to the above-mentioned suitable for the food, there are some patients should not use or eating less, such as figs, milk vetch, rape, the yellow Bullacta and celery should be avoided, such as eating sunlight. Mushroom, mushrooms, mushrooms, and certain food dyes and tobacco also have a potential role for induced systemic lupus erythematosus, but also try not to eat or less edible.
The diet is also critical for patients with lupus nephritis, one of the reasons this is also the reason why always relapse, so rational, scientific diet to arouse the attention of patients and their families with lupus nephritis, this will make effective control. Once a stable condition, you can be like a normal person.

Diffuse lupus glomerulonephritis


Diffuse lupus glomerulonephritis, ISN / RPS 2003 the most controversial amendments to the classification of type Ⅳ LGN, the subtype classification in order to facilitate the study of the pathogenesis, clinical and prognostic parameters. A large number of studies have shown that there are differences, IV S-type LGN Ⅳ G-type LGN prognosis, which may be different in the pathogenesis of various genotyping. In the evaluation of severity, activity and sclerosis lesions have to be taken into account.
Type Ⅳ LGN light microscopy showed thickening of the glomerular capillary wall showed diffuse, platinum ear disease, platinum ear refers to the deposition of immune complexes in the subendothelial capillary wall stiffness, and the occurrence of the refractive index. Transparent thrombosis and capillary wall double-track sign. Other histologic variants include a wide range of subendothelial deposits, capillaries filled with ball inside and outside hyperplasia, inflammatory cell infiltration with mild or moderate immune deposits and glomerular mesangial matrix and mesangial cells hyperplasia. These lesions show the heterogeneity of the vascular lesions of the ball in the LGN. The immunofluorescence visible immune deposits "sold out" phenomenon, namely, the deposition of IgG, but also shows the IgM, IgA and complement composition C3, c4, C1q deposition. Electron microscopy showed that in the mesangial area, the skin, visible in the basement membrane immune complex deposition, visible chunk of subendothelial electron dense. Type Ⅳ LGN observed ultrastructure, such as 5% to 10% of patients in the electron microscope similar cryoglobulinemia "fingerprint-like structures, arranged in parallel by the diameter of 10-15 tim micro-fiber curve composed of . These finger-like structure has not been accompanied by cryoglobulinemia, and more easily observed in the vascular basement membrane can be seen in the tubules and blood vessels surrounding the basement membrane and micro-arterial wall. The majority of patients with positive antibodies and hypocomplementemia. Tubulointerstitial most serious in the III, Ⅳ type, biopsy (particularly long course of patients) suggestive of interstitial lesions, including cell number and the amount of interstitial Tubular interstitial involvement and important sign of a prognosis. Visible in a small number of type IV LGN vascular injury, the performance of vascular immune deposits, lupus vasculopathy accompanied by a large number of non-inflammatory small artery and arteriole endothelial deposits, thrombotic microangiopathy, and occasionally necrotic arteritis.

Focal lupus glomerulonephritis nephritis


Focal lupus glomerulonephritis glomerulonephritis type III LGN almost all of the segmental lesions, and rarely see the ball in the initial study. Lesions showed segmental capillary proliferative lesions with or without crescent formation, necrosis of the capillary wall cellulose; in the development process can occur with focal segmental glomerulosclerosis package's capsule adhesions. Immunoglobulin in the classic mode of immunofluorescence, complement components (C3 and C1q) and light chain (inbound and K) were positive. Activity and chronic glomerular damage performance (Table 3). The activities of electron microscope immune deposits in the endothelium, visible endothelial swelling and a large number of multi-line leukocyte influx. Compared with immunofluorescence and electron microscopy to lack of sensitivity to the diagnosis of type Ⅲ LGN. Ⅲ type LGN. The renal tubules, renal interstitial, and renal vascular disease, common focal interstitial fibrosis and tubular atrophy. Type III LGN pathology report should be included in the glomerular activity and chronicity index, needed for diagnostic activity, chronic disease, the loop necrosis and crescent formation, involving the ratio of glomerular and tubulointerstitial and vascular lesions are described, which help to predict the clinical outcome.

Mesangial proliferative lupus glomerulonephritis


Mesangial proliferative lupus glomerulonephritis II type LGN is to exclude other classification parameters are limited to varying degrees of mesangial cells (≥ 3 / mesangial area) and mesangial matrix increase, with mesangial immune complexesdeposition, so any chronic and active disease are not classified as type Ⅱ. Immunofluorescence immunoglobulin (IgG, IgM and IgA) and complement component (c3, c4, of C1q and cracking prime) positive lead. Immune complexes in the positive immunofluorescence sold-out "phenomenon, the higher the characteristics of LN diagnosis. Immunofluorescence and electron microscopy occasionally scattered subepithelial and subendothelial deposits, but not enough to cause the light microscope, the changes in the vascular wall.
Electron microscope, visible particle type, dense deposits mainly in the mesangial area but can be extended to the subendothelial space next to the mesangial Light microscope under visible glomerular endothelial deposits, or the glomerular ball or segmental scar, should be based on the degree of extent of disease defined as Ⅲ or Ⅳ ¨. Tubulointerstitial and vascular changes in the type Ⅱ LGN is not obvious.

The clinical care of lupus nephritis



The clinical care of lupus nephritis is like? Because lupus nephritis is a stubborn kidney disease, lupus nephritis can easily relapse is very high, so the daily care requirements for patients with lupus nephritis, the slightest mistake will affect the treatment effect. The next the Shijiazhuang nephropathy hospital experts give you details about the daily care of lupus nephritis specification, hoping to cause the majority of patients with lupus nephritis families of great importance to.

Specification of the daily care of patients with lupus nephritis:


The psychological care of patients with lupus nephritis: disease or taking hormone can cause the body to change the appearance, not part of the loss of function of fertility and severe in patients with depressed patients, the ideological burden too heavy to lose confidence in life, to refuse treatment. Family members should talk to patients and allow patients to feel the warmth and love the people around them, to increase confidence in the treatment, and drug reactions are reversible.


General care of patients with lupus nephritis: outdoor activities face can be coated chloroquine cream, wear long-sleeved clothes, wearing wide-brimmed hat to reduce sun exposure to avoid skin lesions. Accommodation should be curtains. Good oral care available 4% soda gargle mouthwash to prevent fungal infection, oral fungal infection delicious containing nystatin 500 000 units three times a day, or 1 --- 4% mold yl solution daily 3-4 times. On the fingers, toes, nose, ear lobes and other parts of the extensive arteritis merger of Raynaud's phenomenon, attention should be warm to prevent limb peripheral frostbite and necrosis.


Patients with lupus nephritis to combat colds and infections: infection should be timely use of antibiotics. Home care patients with lupus nephritis should always combat colds, and attention to the warm warm; after a cold to follow doctor's orders, taking the small renal toxicity of cold medicine, silver fins, such as dimension c Shuanghuanglian oral solution, Radix granules.


Rehabilitation exercises care of patients with lupus nephritis: lupus nephritis patients have adequate sleep, in order to reduce fatigue, may be appropriate to participate in various activities, housework, and a wealth of recreational activities, farmers can light manual labor.


Diet care of patients with lupus nephritis: into the high-calorie, high vitamin, low-salt diet, in addition to renal insufficiency can give high-protein diet, conditional long-term use of milk, especially colostrum, contains a lot of antibodies due to colostrum increase the body's immunity.


Treatment and rehabilitation of many patients with lupus nephritis are very tortuous, and certain to arouse the attention of patients and their families in daily care.


Shijiazhuang kidney disease hospital experts, the introduction of the Notes of the daily care of patients with lupus nephritis. If you want to know more about issues related to lupus nephritis, welcome to contact the Shijiazhuang online nephropathy hospital experts.

What are the symptoms of lupus nephritis?


Nephritis of systemic lupus erythematosus nephritis a timely treatment is apt to cause a series of complications occurred. Understand the symptoms of lupus nephritis can help themselves to better treatment and prevention. What are the symptoms of lupus nephritis?
The symptoms of lupus nephritis in the following areas:
(A) General symptoms: lupus nephritis symptoms of the majority of patients present with malaise, symptoms of lupus nephritis weight loss, 90% of patients have fever, some more than 39 ℃.
(B) of the skin and mucous membrane damage: The majority of patients exposed to the skin at the skin lesions, about half of the patients the symptoms of lupus nephritis, facial butterfly erythema, or hair loss. Visible urticaria symptoms in some patients of lupus nephritis, discoid erythema, the palm of your hand, refers to nail week erythema, purpura.Some of the symptoms of lupus nephritis patients with oral ulcers. These hair loss as the main indicators of the SLE disease activity.
The above analysis of the symptoms of systemic lupus erythematosus nephritis, and hope that would be helpful to the patients! !

How to treat lupus nephritis effectively


Dirty fibrosis, only blocking its progress in order to protect the kidney function. The Editor will lupus nephritis following treatment reasonable? "Described in detail.


Lupus nephritis treatment reasonable?


Lupus nephritis in the clinical treatment is more complicated. If you are patients with lupus nephritis, in the course of treatment, please be sure to note the following:


(1) lupus nephritis should be long-term treatment, some patients even require lifelong treatment. The disease has a strong genetic background, so far, although oral medication can be a good remission of disease, but there are certain side effects, micro-based medicine to penetrate therapy drugs for external use, in the same time to improve efficacy, greatly reducing the drug side effects. Patients in the process of application of the drug do not listen to Youyi unauthorized withdrawal, so that will be detrimental to the treatment of the disease, making it prone to repeated.


(2) installments according to the degree of disease activity in treatment. Lupus in the activities of very serious kidney inflammation usually require large doses of several drugs in combination therapy (such as hormones, Xiao interest, called the induction period of treatment), is designed to quickly control the inflammation, to prevent kidney damage continues to increase. When converted to small doses of drugs in the control of the activity maintenance therapy to prevent recurrence and to protect kidney function (maintenance therapy). Long-term use of large doses of medication will inevitably bring about complications, but without maintenance therapy, repeated activities can be caused by lupus, kidney damage has been increasing, and finally may be developed for renal failure. Therefore, during treatment, according to the lupus activity, timely adjustment of the treatment. Have a long-term planning, should his condition improved random drug withdrawal, or blind to long-term medication.


(3) treatment options vary. Individual severity of patients with lupus nephritis different, there are many types of different patients, different types of different treatment options should be taken. Clinical widespread use of large doses of the hormone in combination with cyclophosphamide intravenous treatment is not suitable for all patients with lupus nephritis. Should be based on clinical disease and renal biopsy under the guidance of a doctor choose to use anti-lupus drug. Long-term maintenance therapy, the combination of Chinese and Western therapy is not only effective, less side effects, patients can also live and work.


(4) pay attention to prevent complications. This point is often overlooked. Lupus nephritis patients in the treatment process is prone to various complications such as infections, cardiovascular complications, femoral head necrosis, severe cases can be life threatening. Key to reducing complications, the key lies in the rational use of anti-lupus drug, regular follow-up to early detection and treatment. The use of large doses of medication, should be relatively isolated, not in public places, and attention to climate change. Fever and other symptoms of infection and timely treatment.


(5) to prevent the recurrence of lupus. Any infection, sunlight, chemicals, contact or pregnancy can induce lupus activity. Female patients should avoid pregnancy, the disease is uncontrolled. Such as pregnancy must also must be under the guidance of a doctor.


(6) stressed the idea of ​​the overall treatment. Because lupus is a systemic disease, so in control lupus nephritis at the same time, you should pay attention to protection of renal function and other vital organs such as heart, lung or brain treatment and protection.


In summary, patients with lupus nephritis must not listen to Youyi and credulous recipe, accept unprofessional, unscientific, non-standard method of treatment. Should choose a formal specialist hospitals, according to the characteristics of their own condition by a doctor to develop a long-term treatment and recovery plan, and regularly checked. So as to effectively control the disease, the greatest extent possible to block the progression of the disease and reduce drug complications and to achieve the best therapeutic effect, in order to maintain a better quality of life and ability to work.

Drugs for Lupus nephritis


Lupus nephritis which therapy is better? Lupus nephritis is a secondary kidney disease, not a separate disease, timely understanding of the patient history to understand the pathogenesis of the patients before they can develop the right treatment. The cause of lupus nephritis main reason is the main reason to cause the wolf Cang nephritis is due to chronic viral infections, genetic, hormonal and environmental factors interact to cause immune deficiency, immune complex deposition resulting in epithelial cells of the synthetic-rich Yin charge barrier function is compromised.
The confirmed wolf Cang nephritis, most hospitals now commonly used in clinical intravenous injection of large doses of hormones in combination with cyclophosphamide treatment, these two drugs can cause a decline of immunity, in addition, the excessive use of antibiotics, but also can easily lead to superinfection of lupus nephritis.
Only timely treatment of the symptoms of lupus nephritis in order to avoid harm, the patient should be selected according to their own situation to heal individuals of varying severity of disease in patients with a variety of types, different types should be taken to a different treatment for different patients, The program is not suitable for all patients.
Wolf Cang nephritis varied, even the original stable condition, under the influence of certain factors, but also activity in the treatment of wolf Cang nephritis patients have to go to the best regular kidney specialist hospital to receive formal treatment, to keep abreast of changes in renal function, it is recommended that the majority of patients with early treatment.
Of micro-penetration therapy of Chinese medicine to fix the intrinsic cells of the kidney damage, kidney disease rule, "this" to avoid the repeated recurrence of the disease. Micro-based traditional Chinese medicine active substances to activate the function of renal intrinsic cells to reverse and restore normal cell metabolism; to improve the microcirculation impaired kidney kidney aerobic repair the environment, accelerate the natural cellular repair of the damage the kidneys; to improve the damaged kidney within environment, reduce the symptoms of poisoning, and create a relaxed environment for kidney repair and reconstruction; with biphasic immunomodulatory function and metabolism, can control the progress of the disease, and lay a good foundation for the repair and reconstruction of the inherent damage kidney cells; for damage renal repair and reconstruction of nutrients to accelerate the repair process of the inherent damage kidney cells, the gradual repair of renal tissue, and reconstruction of renal function.

CanLupus nephritis be cured?


Lupus nephritis can be cured? Lupus nephritis is the renal inherent cell damage caused by lupus cells into the human body, may also be the performance of systemic lupus erythematosus. The traditional approach to the treatment of lupus nephritis is the hormone and immune agents, which to some extent, can temporarily relieve symptoms, can not repair damaged kidney tissue and kidney function, a temporary solution.
Lupus nephritis can be cured? This problem can not be generalized, as long as the patients with the treatment of experts and doctors, can generally be clinical cure, a fraction of patients will be living wills, life with the treatment causing very serious consequences will result in lupus nephritis uremia virtually increase the difficulty of treatment.
To cure for lupus nephritis, the need to combine Chinese and Western medicine, western medicine governance disease, supplement the shortcomings of traditional Chinese medicine effective slow, reducing kidney tissue damage caused by the slow Chinese medicines. After the micro-based medicine to reach lesions, inflammatory factor inactivation, has been the formation of extracellular matrix degradation, repair kidney damage cells and other effects to block the process of renal fibrosis. Chinese medicine active material expansion at all levels of systemic blood vessels, by increasing the effective systemic perfusion, the damaged cells of the blood supply, oxygen, fundamentally alleviate renal ischemia, hypoxia, cells continue to damage to reduce kidney function.
Lupus nephritis in addition to aggressive treatment will affect the cure, the usual personal care is also very important. Patients maintain a good attitude, we must establish the confidence to overcome the disease, positive and optimistic attitude, and the recovery of the disease, I believe that miracles occur in every patient, but also firmly believe that our medical level, there will always overcome lupus nephritis will not be repeated.
3, the principle of the diet of patients with lupus nephritis? 20% of patients with lupus nephritis in 10 years, developed into uremia, because of the high recurrence rate of lupus nephritis, and regular treatment is a very close relationship with patients adhere to a reasonable diet is also inseparable from the , lupus nephritis eat what treatment?

Appropriate food for patients with lupus nephritis


Lupus nephritis in patients with suitable food:
A low-salt foods: corticosteroids, or patients with kidney damage easily lead to water and sodium retention, causing edema, so the low-salt diet.
2, high-quality protein-rich foods: kidney damage in patients with systemic lupus erythematosus often have a lot of protein is lost from the urine, can cause hypoproteinemia is necessary to add enough quality protein, can drink milk, eat more soy. eggs, lean meat, fish and other protein-rich food.
3, low-fat food: less patients with systemic lupus erythematosus activity, poor digestive function, should eat light and easily digestible food unfit for human consumption containing more fat and greasy food. Vitamin-rich vegetables and fruits, to prevent osteoporosis caused by glucocorticoids, eat more vitamin-rich vegetables and fruits.
In addition to the above-mentioned suitable for the food, there are some patients should not use or eating less, such as figs, milk vetch, rape, the yellow Bullacta and celery should be avoided, such as eating sunlight. Mushroom, mushrooms, mushrooms, and certain food dyes and tobacco also have a potential role for induced systemic lupus erythematosus, but also try not to eat or less edible.
The diet is also critical for patients with lupus nephritis, one of the reasons this is also the reason why always relapse, so rational, scientific diet to arouse the attention of patients and their families with lupus nephritis, this will make effective control. Once a stable condition, you can be like a normal person.

Prednisone treatment for lupus nephritis


Prednisone treatment of lupus nephritis effect okay? Prednisone treatment of lupus nephritis through immunosuppression to eliminate the clinical symptoms, the effect is worth it for sure, but the late effect of the majority of patients should be aware of: easy to relapse. Detail below.
Prednisone treatment of lupus nephritis by:
Anti-inflammatory effects: to reduce and prevent tissue response to inflammation, thereby reducing the performance of the inflammation. Hormone inhibition of inflammatory cells, including macrophages and white blood cells gather at the sites of inflammation, and inhibition of phagocytosis, the release of lysosomal enzymes and inflammatory chemical mediators synthesis and release.
Immunosuppressive effect: to prevent or inhibit the cell-mediated immune responses, delayed hypersensitivity reactions, reducing the T lymphocytes, monocytes, eosinophils number to reduce the binding capacity of immunoglobulin with cell surface receptors and inhibit the synthesis and release of interleukin, thereby reducing the T lymphocyte conversion to lymphoblastoid cells, and to mitigate the expansion of the primary immune response. Immune complexes can be reduced through the basement membrane, and can reduce the concentration of complement components and immunoglobulins.
Many patients have a certain effect after taking prednisone treatment, but side effects, but a temporary solution. Prednisone can only suppress the immune response, but can not clear the immune complexes, can not repair damaged renal intrinsic cells, so often repeated the phenomenon of illness. It is proposed to consider the other side effects of drugs, this Shijiazhuang kidney disease hospital on the existing basis of immunosuppressive drugs and technologies, the introduction of foreign, more suitable for immunosuppressive treatment of a range of low side effects of drugs and technologies , first to block the immune response, followed by immune tolerance. Immune complex deposition in the kidney, a short time, the Ministry may be completely eliminated, so let the body work hard to adapt to the fact that pathogenic foreign matter deposited in the kidney tissue to stop the immune response. Immune mediation stage is to enter, adjust the immune system within the work environment and enhance human immunity. On the basis of immune regulation in patients with the introduction of protective immunity stage repair of podocytes and mesangial cells. The last resort is to the immune clearance, according to the actual situation of the patient's immune adsorption, plasma exchange and blood purification.

Friday, July 27, 2012

Diet for lupus nephritis

"Lupus nephritis diet," the majority of patients concern, Shijiazhuang kidney disease hospital for a brief introduction of lupus nephritis diet
1, black beans, red bean, the 30g, 10 red dates, and cook until beans rot can be sugar, daily soup, but also edible small amount of beans. For the kidney, proteinuria. 2, about turtle 500g, plus walnut meat, amount of rock sugar, spices, steamed, used for kidney proteinuria. 3, honeysuckle, chrysanthemum, the 10g, tea right amount of tea to drink. For facial erythema. 4, Astragalus 30g, a broiler chicken, stew. Apply to the hypoproteinemia, edema. 5, Coix seed 15 to 30g, boiled, put the amount of sugar, edible, once daily. Facial erythema.

Lupus nephritis patients how to use hormones and cyclophosphamide


Lupus nephritis patients how to use hormones and cyclophosphamide "issues of concern are the majority of patients, Shijiazhuang kidney disease hospital for a brief introduction of lupus nephritis patients how to use hormones and cyclophosphamide
The traditional drug treatment of lupus nephritis is a hormone, but in recent years, clinical practice shows that, with cytotoxic therapy, especially for intermittent pulse therapy with cyclophosphamide than a simple hormone by the efficacy is much better. Therefore, the treatment of lupus nephritis, cyclophosphamide plus hormones, rather than simply use the hormone. Hormones: (1) The general use of prednisone, the first beginning stages of treatment, adult 1mg/kg, daily morning Dayton clothing, until eight weeks after the reduction, a week less 5mg, small doses (the next day morning 1mg / kg) to the next day morning serving Dayton, continued treatment according to the specific circumstances of the period of time, to continue reduction effect than ideal, until the maintenance dose (the next day morning 0.4mg/kg). Some people think that lupus nephritis patients should be taking hormones for the rest of their lives, the general dosage for prednisone every other day for the morning service 10 20mg. It is noteworthy that the first start of the hormone dose should be enough, inadequate dosage (<30mg / d) is often ineffective, glomerular lesions will continue to progress into fibrosis and lead to irreversible renal failure. The condition is particularly serious or fulminant by high fever up to 40 ° C to a widespread rash and purpura, massive proteinuria, can also be used a large dose steroid pulse therapy. If the unconditional use of methylprednisolone and dexamethasone 150mg / d instead, the effect is also good. Cyclophosphamide (2): can inhibit the activity of lupus nephritis, stabilize the course of the disease, reduce the dosage of hormone, but also inhibit the effect of specific antibody, in particular, the elimination of the non-specific inflammation of lupus nephritis and T lymphocyte-mediated immune also good effect. Studies have shown that cyclophosphamide pulse therapy compared with continued drug use better efficacy and fewer side effects. Each 0.75 1.0g/m2 body surface area, intravenous infusion of foreign use of cyclophosphamide, the impact of 1 to 3 months 1 dose oral prednisone. Improved domestic cyclophosphamide pulse therapy, please refer to the aforementioned content.

The prognosis and treatments for lupus nephritis



Treatment of lupus nephritis points and the prognosis, "the majority of patients concern, Shijiazhuang kidney hospital for brief treatment of lupus nephritis points and the prognosis
Since large doses of adrenal corticosteroids and immunosuppressive agents, the prognosis of this disease has been changed and improved survival. Its treatment of the following elements: (1) early treatment. (2) the pathological type of treatment should be based on kidney damage and active individual. Such as minimal change disease without special treatment, given the amount of hormones to control the systemic manifestations. And diffuse proliferative glomerulonephritis and should be actively treated. (3) combination therapy. (4) chronic renal failure, should be indications for hemodialysis treatment. Prognosis: The disease is a recurrent gradual progress of kidney disease, clinical course quite different
If you have lupus nephritis treatment points and the prognosis is not yet understood, can continue to read the following related content.

Chinese medicine treatment of lupus kidney coup

Chinese medicine treatment of lupus kidney coup "and other issues of concern are the majority of patients, Shijiazhuang kidney hospital for a brief introduction of Chinese medicine treatment of lupus kidney coup
① Hot excessive toxic type of treatment: Zheng Jian fever subside, bleeding tendency, thirst for cold drinks, and even the faint delirium convulsions, or see the joint swelling and pain, red purple, pulse loud or number. The Expelling Qingrejiedu, cooling blood Xiaoban, side rhino horn Di Huang Tang flavors disinfection decoction. See coma delirium, available Angongniuhuang, Zixue; convulsions plus the antelope powder, Uncaria, Scorpion; joint swelling and pain are available Xuanbi Tonga taste. ② liver and kidney: two eyes dry, dysphoria hot, dry mouth and throat, hair off teeth shake, waist and knee pain, dry stool, or low-grade fever night sweats, red urine, burning, dizziness, tinnitus, red tongue, rapid pulse . Expelling nourish hepatorenal side Guishao yellow soup or Qijudihuang, Decoction. Urine hot hematuria, can be used to know Bo Di Huang Tonga verbena, Biota orientalis, the size of thistle; if dizziness, ringing in the ears, and silkworm, chrysanthemum, magnets. ③ spleen deficiency: Zheng Jian malaise, less gas lazy words, aversion to cold, weak waist, heel pain, pay less bloating, loose stools, clear urine, or edema, pale tongue with teeth marks, fur white, pulse delay weakness. Expelling Warming spleen, in the absence of edema, available soup of Xiangsha Liujunzi or Buzhongyiqi Tonga aconite, cinnamon, Curculigo, Epimedium; if the edema, partial Spleen virtual real spleen decoction, partial deficiency Zhenwu Tonga Achyranthes, Plantago. Indulge in the spleen and kidney qi deficiency are Jianpiyishenfang mainly spleen deficiency obvious, Bu Zhong Yi Qi Tang or different power Powder Plus laevigata, dodder seed, psoralen; edema in serious cases, Fangjihuangqi Tang Chun Ze Tang; kidney deficiency obviously can be used to Wu Zi Yan Zong Wan Codonopsis, Astragalus. The ④ Qiyinliangxu: Zheng Jian languid, less gas lazy words, spontaneous perspiration, fear the wind, common cold, fever night sweats, five upset hot, dry mouth and throat, tongue pink or reddish, with scalloped edges, moss thin white, thin veins or breakdown. Expelling Qi and yin, fried addition and subtraction with Shenqidihuang soup or nourishing. If you see the yin and yang can be used to Dihuangyinzi, or the Shenqi Guifu yellow Decoction. 

Treat different types of lupus nephritis


Treatment of lupus nephritis keep type matching issues of concern are the majority of patients, Shijiazhuang kidney disease hospital for brief treatment of lupus nephritis keep matches the type of
Cytotoxic drugs in the treatment of the beginning of the application, can also be added with the hormone is not satisfied with the results. Studies have shown that, added to enhance the efficacy of cytotoxic drugs can reduce the hormone dosage. To cyclophosphamide (CTX) pulse therapy, 750mg/M2 in normal saline slow intravenous infusion in more than one hour, 1 time / month, once every six months. Timely treatment is critical to improve the prognosis of patients with lupus nephritis. Traditional medicines in the treatment of lupus nephritis is a hormone, its dosage should be based on the extent of clinical manifestations and histological changes. Clinical practice, the combination of cytotoxic drugs than simply better the effect of hormone therapy. (1) lupus nephritis workers do not require special treatment, follow-up observation. (2) lupus nephritis type Ⅱ Ⅱ a type only some mild mesangial lesions without treatment; Ⅱ b lesions with proteinuria more than] g/24h serum high titers of anti-dsDNA and low C3 complement The hyperlipidemia prednisone 20mg / d, once every six weeks - 3 months, after reduction to maintain. (3) the same lupus nephritis III type and type Ⅳ two types of treatment options, the prognosis is similar. Because the incidence of ESRD in 10 years up to 50% or more, it should strengthen treatment. 1) glucocorticoids: prednisone-based drugs, conventional dosage of 0,8-1mg, kg_1, d_1, after 8 weeks of treatment, tapering, the reduction rate must be controlled, maintenance treatment to 10_20mg / d for at least two years. Methylprednisolone pulse necessary to give 0,75 g, m2_1 d_1 infusion for three consecutive days as a course. Methylprednisolone followed by prednisone maintenance therapy, efficacy, side effects. Need to be adjusted when the following conditions occurs glucocorticoid medication: difficult to control diabetes or high blood pressure, severe osteoporosis, steroid psychosis, severe infection and severe myopathy. 2) cytotoxic drugs: even without cytotoxic drugs, glucocorticoid treatment of proliferative glomerulonephritis, the treatment more fully in combination with cytotoxic drugs, but cytotoxic drugs often take 3-4 months before onset. Cytotoxic drugs in the treatment of the beginning of the application, can also be added with the hormone is not satisfied with the results. Studies have shown that, added to enhance the efficacy of cytotoxic drugs can reduce the hormone dosage. To cyclophosphamide (CTX) pulse therapy, 750mg/M2 in normal saline slow intravenous infusion in more than one hour, 1 time / month, once every six months. The absence of disease activity every three months the impact of a stable after treatment for 1-2 years may be considered withdrawal. Side effects: In addition to the common side effects, but also the occurrence of menstrual disorders (16% -20%), reproductive failure (19%), hemorrhagic cystitis (17%), bladder (2%). Used in conjunction with small doses of glucocorticoids can enhance efficacy and reduce toxicity. CTX medication need to be adjusted in the following circumstances: refractory hemorrhagic cystitis, severe nausea, vomiting, radiotherapy, previous history of cancer, bone marrow suppression caused by reduced blood cell damage resulting from blood (peripheral blood cells decreased excluded).

Right treatment for lupus nephritis


Treatment of lupus nephritis need to "match" and other issues of concern are the majority of patients, Shijiazhuang kidney hospital for brief treatment of lupus nephritis need to "match"
Timely treatment is critical to improve the prognosis of patients with lupus nephritis. Traditional medicines in the treatment of lupus nephritis is a hormone, its dosage should be based on the extent of clinical manifestations and histological changes. Clinical practice, the combination of cytotoxic drugs than simply better the effect of hormone therapy. (1) lupus nephritis workers do not require special treatment, follow-up observation. (2) lupus nephritis type Ⅱ Ⅱ a type only some mild mesangial lesions without treatment; Ⅱ b lesions with proteinuria more than] g/24h serum high titers of anti-dsDNA and low C3 complement The hyperlipidemia prednisone 20mg / d, once every six weeks - 3 months, after reduction to maintain. (3) the same lupus nephritis III type and type Ⅳ two types of treatment options, the prognosis is similar. Because the incidence of ESRD in 10 years up to 50% or more, it should strengthen treatment. 1) glucocorticoids: prednisone-based drugs, conventional dosage of 0.8 1mg.kg_1. D_1, eight weeks after treatment began to gradually decrease, the reduction rate must be controlled, maintenance treatment to 10_20mg / d for at least two years . Necessary to give methylprednisolone, 0.75g.m2_1. D_1 intravenous infusion for three consecutive days as a course. Methylprednisolone followed by prednisone maintenance therapy, efficacy, side effects. Need to be adjusted when the following conditions occurs glucocorticoid medication: difficult to control diabetes or high blood pressure, severe osteoporosis, steroid psychosis, severe infection and severe myopathy. 2) cytotoxic drugs: even without cytotoxic drugs, glucocorticoid treatment of proliferative glomerulonephritis, the treatment more fully in combination with cytotoxic drugs, but cytotoxic drugs often take 3-4 months before onset. Cytotoxic drugs in the treatment of the beginning of the application, can also be added with the hormone is not satisfied with the results. Studies have shown that, added to enhance the efficacy of cytotoxic drugs can reduce the hormone dosage. To cyclophosphamide (CTX) pulse therapy, 750mg/M2 in normal saline slow intravenous infusion in more than one hour, 1 time / month, once every six months. The absence of disease activity every three months the impact of a stable after treatment for 1-2 years may be considered withdrawal. Side effects: In addition to the common side effects, but also the occurrence of menstrual disorders (16% -20%), reproductive failure (19%), hemorrhagic cystitis (17%), bladder (2%). Used in conjunction with small doses of glucocorticoids can enhance efficacy and reduce toxicity. CTX medication need to be adjusted in the following circumstances: refractory hemorrhagic cystitis, severe nausea, vomiting, radiotherapy, previous history of cancer, bone marrow suppression caused by reduced blood cell damage resulting from blood (peripheral blood cells decreased excluded). 3) 30% -50% of patients with lupus nephritis poor response to the above treatment, especially nephrotic syndrome. Most of the patients at the onset of treatment of 4-6 months to 9-15 months to the above therapy tolerance. You can take the following measures: ① a monthly infusion of CTX, once every six months, at the same time increase the impact of methylprednisolone; (2) was added azathioprine in combination with prednisone and CTX infusion can also be CTX replaced by small doses of oral; (3) the addition of plasma exchange, carried out simultaneously with the CTX treatment; ④ appropriate to increase the amount of glucocorticoid. 4) lupus acute exacerbation of: deterioration of renal function, methylprednisolone or plasma exchange, which is particularly associated with cryoglobulinemia, hyperviscosity, or thrombotic thrombocytopenic purpura patients. 5) Azathioprine: usually as second-line drugs, wide foreign application that is safer, even pregnancy, the patient only occasionally teratogenic, can delay the progress of chronic kidney damage, the combination allows acute kidney disease and methylprednisolone quickly ease. 6) mycophenolate mofetil (MMF, trade name Cellcept): can be used for the treatment of diffuse proliferative lupus nephritis, at home and abroad has been a small sample of reports, has a certain effect. 7) other immunosuppressive therapy: Methotrexate: 6 months of the glucocorticoid treatment is invalid, the trial of methotrexate 15mg / w. Cyclosporine A: The dose of 2.5-5mg.kg_1. D_1, mainly used in the conventional-therapy patients; main side effects are nephrotoxicity, hypertension and abnormal liver function. Has also started anti-CD4 monoclonal antibody drugs for clinical use. Occasionally also be used chlorambucil, nitrogen mustard or whole lymph node area radiation (TLl) therapy. 8) anticoagulant therapy: dipyridamole 100mg orally, three times the old; 60 000 U of urokinase infusion, 1/14 days for a course; low molecular weight heparin and hirudin treatment also can get better effect. 9) Other treatment: male hormone DHEA (dehydroepiandrosterone androstane ketones), hydroxychloroquine, dopamine antagonists bromoefiptine and 2 - chloro-deoxyadenosine, etc. can achieve a certain effect. The effect of plasma exchange or plasma separation is not ideal and necessary with the immunosuppressive therapy. The autologous bone marrow T-cell reinfusion only individual cases of success. Lupus nephritis in patients with end stage renal failure must be considered a replacement therapy for peritoneal dialysis, hemodialysis, kidney transplantation. (4) lupus nephritis Ⅴ are generally accompanied by varying degrees of proliferative lesions, treatment options, and type IV lupus nephritis. May be prednisone lmg kg_1. D_1 after 6-12 weeks of treatment, was reduced to 10mg / d for 1-2 years. Simple membrane lesions are rare, accounting for only 15% of the cases of renal biopsy in type Ⅴ lupus nephritis. (5) when the patient's serum creatinine long-term to exceed 3mg/dL or long-standing chronic index, you should note the following: ① unless there is a higher activity index, usually do not advocate the use of a strong treatment programs; ② treatment of renal Lupus usually give prednisone 5-10mg / d to maintain; the ③ salt and protein intake should be limited, and to monitor changes in blood pressure.