What cause lupus nephritis

This disease is the body's endogenous (self) antigen by the immune complex diseases and disorders associated with T cell function. To be investigated in the patients serum antibodies have a variety of anti-autologous tissue composition, including anti-DNA antibodies, especially anti-double stranded DNA (natural DNA) antibody is more effective than positive, patients with circulating immune complexes separable into natural and single-stranded DNA antibodies and antigens; eluted from glomerular immunoglobulin antibody can be combined with natural and single-stranded DNA antigen.
A humoral immune changes in which DNA and anti-DNA antibodies form immune complexes play a major role. (1) virus triggering factors: more studies confirm the disease is an RNA virus - type C virus. C-type virus on the one hand may damage the cells, so that the release of DNA was highly immunogenic; the other hand, may be due to this virus reverse transcriptase, the virus's own RNA copied into DNA, leaving the body to produce anti-DNA antibodies, both anti-viral replication generated by DNA, but also against human DNA. (2) Bacterial toxins and lipopolysaccharide trigger factors: Some bacterial lipopolysaccharide composition injected into mice and observed that can contribute to the DNA of mouse tissue release to the blood circulation and the role of mitogen to promote the activation of B lymphocytes to produce antibodies, so that these substances promote the role of DNA antigen-antibody complex to generate. (3) autologous tissue damage to the release of DNA: the patients in vivo lymphocyte cytotoxic antibodies. Medium molecular weight soluble DNA immune complexes through the blood circulation to the kidneys (or other organs) and deposited in the glomerulus.
Cellular immunity: the suppressor T cell function and decline in the number. The reason is that the existence of cytotoxic antibody (anti-lymphocyte or thymocyte antibody) in serum, thereby undermining the T cells. Decreased suppressor T cells, on the one hand, to reduce the inhibition of antibody formation, on the other hand may be due to the release of lymphokines decreased to inactivate the ability of helper T cells, helper T cells to promote antibody production capacity increase, the total The humoral immune (antibody formation) strong.
(3) genetic factors, patients who have family history of the same disease accounted for 0.4% to 3.4.