Sunday, July 29, 2012

Clinical manifestations of lupus nephritis in children


Clinical manifestations of lupus nephritis in children Child lupus nephritis are the majority of patients concern, Shijiazhuang kidney disease hospital a brief introduction to the clinical manifestations of lupus nephritis in children
Clinical manifestations of lupus nephritis in children
Children with systemic lupus erythematosus (SLE) is a typical self-reactive disorder characterized by autoantibodies in children with blood in large amounts of anti-nuclear antigen, and the performance of multi-system damage. The highest of disease onset, rate of girls in Asia. The main clinical manifestations are the following:
A. Onset age and sex: more common in women, accounting for about 80 to 90 percent in pediatric cases aged 10-14 years, the most common, accounting for 1/3 5 to 10 years of age of onset, infants and young children is rare.
Two. Performance of kidney damage: the early course of 25 to 50% of urine or renal dysfunction, future development to 80 percent of the children apparently kidney damage performance, more common than in adults.
(1) Clinical manifestations: no characteristics, hematuria, proteinuria, hypertension is more common: urinary protein is almost there, with varying degrees of edema, 50% right and left with nephrotic syndrome; persistent microscopic hematuria is common but there is no separate the existence of coverage; 40 percent have high blood pressure. About 50% decline in renal function and even can be manifested as acute renal failure. Often tubular dysfunction. Clinical classification: asymptomatic hematuria or urinary protein, acute nephritis, nephrotic syndrome, rapidly progressive glomerulonephritis, acute renal failure, chronic nephritis, acute renal tubular acidosis.
(2) the time: as the first symptom; or systemic symptoms appear several years after, according to the statistics 60% of LN onset of March, 88 percent in three years, while 27% of renal involvement occurs in the pathogenesis of After five years or more.
3. Extrarenal manifestations
(1) rash: facial butterfly rash common sun intensified.
(2) joint symptoms: joint and muscle pain may involve the limbs, the size of joint, showing acute inflammatory process.
(3) cardiovascular anomalies: The lesions may involve the endocardium, myocardium and pericardium, a few may have vasculitis, and Raynaud's phenomenon.
(4) Respiratory: interstitial pneumonia, pleurisy, pleural effusion.
(5) of the nervous system: mild involvement common, such as judgment, short-term memory loss, abnormal behavior, headache. In addition, acceptable performance of the relatively rare mental illness, chorea, convulsions.
(6) Gastrointestinal: mild gastrointestinal tract involvement common, such as nausea, anorexia, abdominal pain, liver or spleen of 30 to 40 percent.
(7) of the blood system with the most common: anemia, followed by white blood cells, thrombocytopenia.
(8) Other: fever, malaise, weight loss, photosensitivity, hair loss and swollen lymph nodes, etc.
These are the clinical manifestations of lupus nephritis in children, hoping to help the parents and friends! If your child has these symptoms, please go to regular hospitals, so as not to delay the child's treatment.

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