Prognosis and treatment of lupus nephritis

Prognosis and treatment of lupus nephritis "are the majority of patients concern, Shijiazhuang kidney disease hospital a brief introduction to the prognosis and treatment of lupus nephritis
Prognosis and treatment of lupus nephritis lupus nephritis type is divided into six types, is different for each type of disease treatment, the prognosis is different. In the traditional areas of the treatment of lupus nephritis is the use of hormonal drugs, the dosage is to change the degree of clinical manifestations and disease and lupus nephritis.
The prognosis and treatment of lupus nephritis type Ⅰ:
The renal tissue of lupus nephritis type Ⅰ, light microscope, normal structure, immunoglobulin and complement deposition in the use of immunofluorescence. The prognosis of this type of lupus nephritis does not require special treatment, but still need follow-up study to prepare for any eventuality.
The prognosis and treatment of type II lupus nephropathy:
Lupus nephritis type Ⅱ, this type of renal injury in glomerular mesangial area, which no mesangial cell proliferation is known as type Ⅱ A, these are mild mesangial lesions prognosis without treatment; Ⅱ B lesions mesangial area seen in mesangial cells and mononuclear cell proliferation, to urinary protein 1g/24h and low complement C3 hyperlipidemia accompanied in the treatment of the need for six weeks between -3 treatment, usually with prednisone 20mg / d, continued with the improvement in reduction of the disease remain. Type Ⅱ lupus nephritis interstitial and vascular damage.
Prognosis and treatment of type Ⅲ and type Ⅳ lupus nephritis:
Type Ⅲ glomerular damage in lupus nephritis has been more significant, In addition to the mesangial focal stage glomerular capillary has been involved, but no more than 50% of the total glomerular Lupus nephritis type Ⅳ and Ⅲ type of the type of injury, only the damage is more extensive than 50% glomerular damage, and even more serious degree.
Pathological damage similar between the two treatment programs similar prognosis.Development of the two types of lupus nephritis in 10 years to end stage renal disease more than 50 percent, so we must strengthen the treatment to prolong the survival period of the two types of patients, is quite important. Under normal circumstances in the prognosis of treatment with glucocorticoids and cytotoxic drugs. The glucocorticoid prednisone-based, conventional dosage advice of a doctor, and the need to maintain a specific time we must obey the doctor's orders. If necessary time to give methylprednisolone maintenance treatment, that the efficacy and side effects. Cell poison drug is also commonly used treatment, glucocorticoid with the cell poison, drug combination more fully. But the cytotoxic onset interval is longer, often 3-4 months before onset.
The prognosis and treatment of lupus nephritis type Ⅴ:
Ⅴ type of lupus nephritis is divided into four types, type Ⅴ, a comparison with patients with idiopathic membranous nephropathy; type Ⅴ b diffuse mesangial changes; Ⅴ type c there are segmental proliferation or segmental sclerosis ; Ⅴ d-exist with diffuse proliferative glomerulonephritis, similar regardless of clinical manifestations of this type, or histological type Ⅴ lupus nephritis.
The type of lupus nephritis treatment to distinguish between what are membranous lupus nephritis or diffuse lupus kidney disease, drugs and treatment approaches used by different pathological distinct, but also to the type of symptomatic treatment.
Ⅵ lupus kidney disease prognosis and treatment:
Ⅵ type of lupus nephritis are the end of lupus nephritis, lupus nephritis type accounts for only 2%.
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