Friday, August 3, 2012

Treatment Principles for allergic purpura nephritis


When allergic purpura kidney damage, known as Henoch-Schonlein purpura nephritis. Allergic purpura kidney damage rate of 30% to 50%. The disease occurs in children, domestic pediatric reports, allergic purpura nephritis accounted for 8% of the hospitalized pediatric urinary tract diseases, ranks third. The treatment of this disease the following principles:


(1) general treatment in patients with acute attention to rest, severe, should rest in bed. Found very important and remove allergens that can cause food allergies, drug should be used sparingly or avoid using, if necessary, desensitization therapy.


(2) symptomatic treatment of mild cases of the natural course of a well, the majority of cases after symptomatic treatment can be fully recovered. Available chlorphenamine (chlorpheniramine), diphenhydramine and other oral; or 0.25% procaine (Novocain) 100ml, plus a lot of vitamin C intravenous drip.


(3) corticosteroids and immunosuppressant treatment of nephrotic syndrome, corticosteroids plus immunosuppressive agents may be given comprehensive treatment. Such as prednisone daily 1 2mg/kg, cyclophosphamide daily 2 3mg/kg, depending on the condition of continuous rejection 6 to 12 months.


Crescent of more than 50%, showing a rapidly progressive glomerulonephritis who can use quadruple therapy (corticosteroids + immunosuppressant + dipyridamole + heparin, warfarin forest), methylprednisolone (methyl prednisolone) pulse therapy and plasma exchange therapy and other treatment. Generally believed that the good effect, but it should be an early application, post-drug effect is not ideal.


(4) end-stage renal failure treatment can be given dialysis or kidney transplantation in the treatment of kidney transplantation, about 1/3 recurrence.

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