Thursday, August 2, 2012

The treatment principles for renal anemia


Renal anemia, anemia due to impaired renal function. The reason, renal anemia of renal erythropoietin (EPO) to produce insufficient, or some toxic substances in the uremic plasma interfere with the red blood cell formation and metabolism caused by anemia caused by various factors. Renal anemia, as normal cells, normal pigment anemia, is one of the clinical manifestations of chronic renal failure. General began to emerge from the renal insufficiency, with the deterioration of renal function, the degree of anemia with the heavier. The treatment of renal anemia, has been a thorny issue in the clinical treatment principles are as follows:


(1) clinical applications to promote application of erythropoietin erythropoietin and renal anemia symptoms significantly improved, physical strength increased, increased appetite, hemoglobin and hematocrit increased. Erythropoietin (EPO) formulations, dose-dependent agents, the effective dose for the daily 50 ~ 150U/kg, intravenous or subcutaneous injection, can start small dose every 2 to 4 weeks of dose adjustment time; also start from the high-dose when the hemoglobin reach 100 ~ 120g / L, the tapering. Hemodialysis or peritoneal dialysis patients, the initial dose of weekly 100 ~ 150g/kg, can be subcutaneous or intravenous injection. Often in the two weeks after the injection began to appear efficacy, four weeks after a noticeable effect, can reach 8 to 12 weeks after the scheduled target of 100 to 120g / L


(2) the improvement of the dialysis blood or peritoneal dialysis treatment for renal anemia will certainly help, especially in peritoneal dialysis effect is better. Dialysis treatment, in addition to induced hemolytic uremic toxins inhibiting factor and erythropoietin relevant.


(3) intramuscular injection of male hormone intramuscular injection of male hormone, can promote the secretion of erythropoietin and erythroid stem cell proliferation, thereby improving anemia. Under normal circumstances, four weeks later, the male hormone, to a significant effect.


(4) severe anemia of chronic renal failure who lose new blood, particularly when myocardial ischemia or severe heart failure, should be given small doses several times lost the fresh blood in order to improve the symptoms of anemia.

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